PRP and Peptides for Chronic Tendon Injuries - Tennis Elbow and Achilles Tendonitis
By: Dr. Tennant, Dr. Shefery, Dr. Nasser
Chronic tendonitis, particularly in conditions like tennis elbow (lateral epicondylitis) and Achilles tendonitis, can be challenging to treat due to persistent pain and degeneration of tendon fibers. Traditional treatments such as rest, physical therapy and anti-inflammatory medications often provide limited relief, prompting interest in regenerative medicine options like platelet-rich plasma (PRP) therapy and peptides. These therapies aim to promote tissue healing and restore tendon function by leveraging the body's natural repair mechanisms.
PRP therapy is a widely studied regenerative treatment that involves extracting a patient’s blood, processing it to concentrate the platelets, and injecting it into the affected tendon. Platelets contain growth factors that play a crucial role in healing by stimulating cell regeneration and reducing inflammation. Research on PRP for tennis elbow has produced mixed results, with some studies showing significant pain relief and functional improvement, while others indicate no clear advantage over conventional treatments. A meta-analysis published in The American Journal of Sports Medicine found that PRP injections provided superior long-term pain relief compared to corticosteroids or placebo. However, outcomes can vary depending on the severity of tendon degeneration, injection techniques and individual patient responses.
For Achilles tendonitis, PRP therapy has shown potential in promoting tendon healing, particularly in cases that do not respond to conservative treatments. A randomized controlled trial published in The Journal of Bone and Joint Surgery reported that patients receiving PRP experienced improved pain relief and function compared to those undergoing standard physical therapy alone. However, some studies have questioned the effectiveness of PRP, noting that benefits may be marginal without proper rehabilitation protocols. The ongoing debate underscores the importance of patient selection and proper application of PRP to maximize its therapeutic effects.
Peptide therapy is another emerging approach in the treatment of chronic tendonitis. Peptides are short chains of amino acids that influence various biological processes, including tissue repair and inflammation modulation. BPC-157 and TB-500 are two peptides commonly discussed for tendon and ligament healing. BPC-157, derived from gastric proteins, has been shown in animal studies to accelerate tendon and ligament repair by promoting blood vessel formation and reducing oxidative stress. TB-500, a synthetic version of thymosin beta-4, is believed to enhance cell migration and repair damaged tissue. While these peptides hold promise, clinical research on their efficacy for human tendonitis remains limited, and their use is not yet widely standardized in medical practice.
Given the complexity of chronic tendon injuries and the evolving nature of regenerative therapies, it is essential for patients to seek care from board-certified physicians or surgeons specializing in orthopedic and sports medicine. Proper diagnosis and treatment planning are critical to achieving the best outcomes. Experienced practitioners can assess whether PRP, peptides, or a combination of therapies is appropriate based on a patient’s condition, medical history, and treatment goals.
As regenerative medicine continues to advance, PRP and peptide therapies offer hope for those suffering from chronic tendonitis. While research supports their potential, ongoing studies are needed to refine treatment protocols and determine optimal applications. Patients considering these options should consult with qualified healthcare providers such as Regenerative Orthopedic Solutions (ROS) to ensure safe and effective care tailored to their individual needs.
For more information to schedule an appointment, visit: www.regenorthosolutions.com
Written by our fellowship-trained physicians at Regenerative Orthopedic Solutions; Dr. Tennant, Dr. Sherfey, & Dr. Nasser. With over 60 years of combined experience in orthopedic trauma, joint replacement, sports medicine, pain management and regenerative therapies. Fellowship-trained at prestigious institutions, our physicians have treated thousands of patients with innovative techniques.
